Gao J, He Q, Subudhi S, Aparicio A, Zurita-Saavedra A, Lee D H, Jimenez C, Suarez-Almazor M, Sharma P
Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Department of Endocrine Neoplasia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Oncogene. 2015 Oct;34(43):5411-7. doi: 10.1038/onc.2015.5. Epub 2015 Feb 9.
Targeting a T-cell inhibitory checkpoint with the anti-CTLA-4 monoclonal antibody, ipilimumab, represents a scientific breakthrough in immunotherapy for the treatment of cancer. However, ipilimumab therapy is also associated with unique side effects, known as immune-related adverse events (irAEs), which need to be recognized and managed with immunosuppressive agents. To date, the majority of our knowledge regarding ipilimumab-associated side effects is based upon clinical studies in melanoma. Here we provide a review of ipilimumab-induced irAEs and our experience in a cohort of 44 patients with prostate cancer who were treated at the MD Anderson Cancer Center on two different clinical trial protocols.
使用抗细胞毒性T淋巴细胞相关蛋白4(CTLA-4)单克隆抗体伊匹木单抗靶向T细胞抑制性检查点,是癌症免疫治疗领域的一项科学突破。然而,伊匹木单抗治疗也伴有独特的副作用,即免疫相关不良事件(irAE),需要使用免疫抑制剂来识别和处理。迄今为止,我们关于伊匹木单抗相关副作用的大部分知识都基于黑色素瘤的临床研究。在此,我们综述了伊匹木单抗诱发的免疫相关不良事件,并分享我们在MD安德森癌症中心按照两项不同临床试验方案治疗的44例前列腺癌患者队列中的经验。