轻度急性间质性胰腺炎再喂养不耐受的危险因素：323 例回顾性研究。

Risk factors of refeeding intolerance in mild acute interstitial pancreatitis: a retrospective study of 323 patients.

机构信息

Department of Anesthesiology & Intensive Care Unit, South Branch, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.

出版信息

Pancreatology. 2015 Mar-Apr;15(2):111-4. doi: 10.1016/j.pan.2014.12.002. Epub 2015 Jan 22.

DOI:10.1016/j.pan.2014.12.002

PMID:25660282

Abstract

OBJECTIVES

This study was aimed to access the frequency and identify independent risk factors of refeeding intolerance in patients with mild acute interstitial pancreatitis.

MATERIALS AND METHODS

Patients with mild acute pancreatitis (AP) were included in this observational, descriptive, and retrospective study. Clinical variables, therapy-related variables, and biochemical and radiological variables were analyzed by univariate and multivariate analysis.

RESULTS

Of 323 included cases, 40 patients (12.4%) developed refeeding intolerance. In the final regression model, hypertriglyceridemia-induced AP (odds ratio, 7.72; 95% CI: 2.50-23.82, P < 0.001), elevated serum lipase (>2-fold of the upper limit of normal) before refeeding (odds ratio, 2.13; 95% CI: 1.2-3.77, P = 0.009), and immediate feeding (odds ratio, 1.75; 95% CI: 1.31-2.33, P < 0.001) were critical risk factors of refeeding intolerance.

CONCLUSION

Refeeding intolerance occurs in 12.4% patients with mild AP and appears more often in those with hypertriglyceridemia-induced AP, elevated serum lipase (>2-fold of the upper limit of normal) before refeeding, and immediate feeding.

摘要

目的

本研究旨在评估轻度急性间质性胰腺炎患者再喂养不耐受的频率，并确定其独立的危险因素。

材料和方法

本研究为一项观察性、描述性和回顾性研究，纳入了轻度急性胰腺炎（AP）患者。通过单因素和多因素分析，对临床变量、治疗相关变量、生化和影像学变量进行了分析。

结果

在纳入的 323 例患者中，有 40 例（12.4%）发生了再喂养不耐受。在最终的回归模型中，高脂血症诱导的 AP（比值比，7.72；95%可信区间：2.50-23.82，P<0.001）、再喂养前血清脂肪酶升高（比值比，2.13；95%可信区间：1.2-3.77，P=0.009）和即刻喂养（比值比，1.75；95%可信区间：1.31-2.33，P<0.001）是再喂养不耐受的关键危险因素。