白塞病及其合并症：国内病例报告与文献综述

Behçet's disease and comorbidity: internal case reports and literature review.

作者信息

Alekberova Zemfira, Gorodetskiy Vadim, Izmailova Fatima, Radenska-Lopovok Stefka, Talybova Elnura, Evsikova Margarita, Timoshin Nikolai, Nasonov Evgeni

机构信息

Nasonova Research Institute of Rheumatology, Moscow, Russia.

State Budgetary Health-Care Agency, Municipal Clinical Hospital, No. 7, Moscow Health-Care Department, Moscow, Russia.

出版信息

Rheumatol Int. 2015 Oct;35(10):1743-7. doi: 10.1007/s00296-015-3232-2. Epub 2015 Feb 13.

DOI:10.1007/s00296-015-3232-2

PMID:25677835

Abstract

The aim of this study was to determine the clinical characteristics of two patients with malignancy related to Behçet's disease. We reviewed literary-reported cases of Behçet's disease related to myelodysplastic syndrome, neoplasm and leukemia. Our own observation included two cases of comorbid conditions of Behçet's disease. The first patient with Behçet's disease had been examined concurrent development of intestinal tumor. The second one was diagnosed to have chromic myeloleukemia. The malignant transformation of Behçet's disease patients, both solid and hematological, is rather rare. Further accumulation of relevant date and its analysis will allow to find out the relationship between malignant disease and chemotherapy in Behçet's disease.

摘要

本研究的目的是确定两名与白塞病相关的恶性肿瘤患者的临床特征。我们回顾了文献报道的与骨髓增生异常综合征、肿瘤和白血病相关的白塞病病例。我们自己的观察包括两例白塞病合并症病例。第一例白塞病患者同时被检查出患有肠道肿瘤。第二例被诊断为慢性粒细胞白血病。白塞病患者发生实体和血液系统恶性转化相当罕见。进一步积累相关数据并进行分析将有助于找出白塞病中恶性疾病与化疗之间的关系。