Cho Kyoo Ho, Kim Young Dae, Kim Jinkwon, Ye Byoung Seok, Heo Ji Hoe, Nam Hyo Suk
Department of Neurology, Yonsei University College of Medicine, Seoul, Korea.
Neurologist. 2015 Feb;19(3):79-81. doi: 10.1097/NRL.0000000000000015.
The triad of ocular tilt reaction (OTR) is conjugated ocular torsion, skewed deviation, and head tilt. A lesion involving below the inferior pons develops ipsiversive OTR, whereas a lesion above the inferior pons leads to contraversive OTR. A lateral medullary infarction usually causes ipsiversive OTR. This is the first report of contraversive OTR following the lateral medullary infarction.
A 58-year-old woman was admitted due to sudden-onset vertigo and gait disturbance. A neurological examination revealed OTR to the left side (left head tilt, leftward ocular torsion, and skew deviation). Lateropulsion to the right and dysmetria on the right arm and leg were present. Diffusion-weighted MRI revealed an acute infarction of the right lateral medulla and the posterolateral pons. The patient slowly improved and can walk without sway after 1 week. Neither head tilt nor ataxia was observed after 3 months.
Lateral medullary lesion typically results in ipsilateral OTR. Contraversive OTR of our patient might be derived from the disruption of the cerebellovestibular inhibitory pathway by the lesion in the juxtarestiform body in the lateral medulla.
眼倾斜反应(OTR)三联征包括眼球共轭扭转、斜视和头倾斜。累及脑桥下部以下的病变会导致同侧眼倾斜反应,而脑桥下部以上的病变会导致对侧眼倾斜反应。外侧延髓梗死通常会引起同侧眼倾斜反应。这是首例关于外侧延髓梗死后出现对侧眼倾斜反应的报告。
一名58岁女性因突发眩晕和步态障碍入院。神经系统检查发现向左的眼倾斜反应(左侧头倾斜、左眼扭转和斜视)。存在向右的侧推症以及右臂和右腿的辨距不良。弥散加权磁共振成像显示右侧外侧延髓和脑桥后外侧急性梗死。患者病情逐渐好转,1周后可无摇晃行走。3个月后未观察到头倾斜和共济失调。
外侧延髓病变通常导致同侧眼倾斜反应。我们患者的对侧眼倾斜反应可能源于外侧延髓近髓帆状体病变对小脑前庭抑制通路的破坏。