脆性X智力低下蛋白：RNA结合蛋白介导翻译调控的范例
Fragile X mental retardation protein: A paradigm for translational control by RNA-binding proteins.
作者信息
Chen Eileen, Joseph Simpson
机构信息
Department of Chemistry and Biochemistry, University of California at San Diego 9500 Gilman Drive, La Jolla, CA 92093-0314, USA.
Department of Chemistry and Biochemistry, University of California at San Diego 9500 Gilman Drive, La Jolla, CA 92093-0314, USA.
出版信息
Biochimie. 2015 Jul;114:147-54. doi: 10.1016/j.biochi.2015.02.005. Epub 2015 Feb 17.
Abstract
Translational control is a common mechanism used to regulate gene expression and occur in bacteria to mammals. Typically in translational control, an RNA-binding protein binds to a unique sequence in the mRNA to regulate protein synthesis by the ribosomes. Alternatively, a protein may bind to or modify a translation factor to globally regulate protein synthesis by the cell. Here, we review translational control by the fragile X mental retardation protein (FMRP), the absence of which causes the neurological disease, fragile X syndrome (FXS).
摘要
翻译控制是一种用于调节基因表达的常见机制，在从细菌到哺乳动物的生物中均有发生。通常在翻译控制过程中，一种RNA结合蛋白会与mRNA中的独特序列结合，以调节核糖体的蛋白质合成。或者，一种蛋白质可能会与翻译因子结合或对其进行修饰，从而全面调节细胞的蛋白质合成。在此，我们综述了脆性X智力低下蛋白（FMRP）的翻译控制，该蛋白的缺失会导致神经疾病——脆性X综合征（FXS）。
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