从中华开口箭新鲜根茎中提取的三种螺旋甾烷醇皂苷和一种黄烷-O-葡萄糖苷。
Three spirostanol saponins and a flavane-O-glucoside from the fresh rhizomes of Tupistra chinensis.
作者信息
Xiao Yan-Hua, Yin Hai-Long, Chen Li, Tian Yin, Liu Shi-Jun, Zhang Guang-Jie, Chen Heng-Wen, Jin Hong, Li Bin, Dong Jun-Xing
机构信息
Beijing Institute of Radiation Medicine, Beijing 100850, China; Institute of Chemical Defense, Beijing 102205, China.
Humanwell Healthcare Group Co., Ltd, Wuhan 430075, China.
出版信息
Fitoterapia. 2015 Apr;102:102-8. doi: 10.1016/j.fitote.2015.02.008. Epub 2015 Feb 21.
Four new compounds, including three new spirostanol saponins [tupistroside G-I (1-3)] and a new flavane-O-glucoside [tupichiside A (4)], together with ten known compounds, were isolated from the fresh rhizomes of Tupistra chinensis. The structures of the new compounds were elucidated by spectroscopic analysis and chemical evidence. All compounds were tested in vitro for their cytotoxic activities against the Human LoVo and BGC-823 cell lines, and six of them were found to possess potent cytotoxicity. Compounds 2, 8 and 9 showed significant cytotoxicity against the tested tumor cell lines with IC50 values ranging from 0.2 to 0.9μM.
从中华开口箭的新鲜根茎中分离得到了4个新化合物，包括3个新的螺旋甾烷醇皂苷（开口箭皂苷G - I，1 - 3）和1个新的黄烷 - O - 葡萄糖苷（开口箭苷A，4），以及10个已知化合物。通过光谱分析和化学证据确定了新化合物的结构。所有化合物均进行了体外抗人LoVo和BGC - 823细胞系的细胞毒活性测试，发现其中6个具有较强的细胞毒性。化合物2、8和9对测试的肿瘤细胞系显示出显著的细胞毒性，IC50值在0.2至0.9μM之间。
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