Li Yuhong, Shi Changhua, Lu Guobing, Xu Qian, Liu Shaochen
Chengde Medical University, Chengde 067000, Hebei Province, China.
Neural Regen Res. 2012 Jun 5;7(16):1248-55. doi: 10.3969/j.issn.1673-5374.2012.16.007.
In this study, we investigated the effects of mobile phone radiation on spatial learning, reference memory, and morphology in related brain regions. After the near-field radiation (0.52-1.08 W/kg) was delivered to 8-week-old Wistar rats 2 hours per day for 1 month, behavioral changes were examined using the Morris water maze. Compared with the sham-irradiated rats, the irradiated rats exhibited impaired performance. Morphological changes were investigated by examining synaptic ultrastructural changes in the hippocampus. Using the physical dissector technique, the number of pyramidal neurons, the synaptic profiles, and the length of postsynaptic densities in the CA1 region were quantified stereologically. The morphological changes included mitochondrial degenerations, fewer synapses, and shorter postsynaptic densities in the radiated rats. These findings indicate that mobile phone radiation can significantly impair spatial learning and reference memory and induce morphological changes in the hippocampal CA1 region.
在本研究中，我们调查了手机辐射对相关脑区空间学习、参考记忆及形态学的影响。将近场辐射（0.52 - 1.08 W/kg）每天照射8周龄的Wistar大鼠2小时，持续1个月，之后使用Morris水迷宫检测行为变化。与假照射大鼠相比，照射大鼠表现出行为能力受损。通过检查海马体突触超微结构变化来研究形态学改变。使用物理分割器技术，对CA1区锥体细胞数量、突触轮廓及突触后致密物长度进行立体定量分析。辐射大鼠的形态学变化包括线粒体退化、突触减少及突触后致密物缩短。这些发现表明，手机辐射可显著损害空间学习和参考记忆，并诱导海马CA1区发生形态学改变。
Zotero 插件
