Assignment of the gene(s) involved in the expression of the proliferation-related Ki-67 antigen to human chromosome 10.

作者信息

Schonk D M, Kuijpers H J, van Drunen E, van Dalen C H, Geurts van Kessel A H, Verheijen R, Ramaekers F C

机构信息

Department of Human Genetics, University Hospital of Nijmegen, The Netherlands.

出版信息

Hum Genet. 1989 Oct;83(3):297-9. doi: 10.1007/BF00285178.

The antigen recognized by the monoclonal antibody Ki-67 is a proliferation-related nucleolus-associated constituent used as a marker for cycling cells in tumor diagnosis. Antibody Ki-67 reacts with human proliferating cells, but not with hamster and mouse cells. Expression of the Ki-67 antigen was studied in a panel of human-rodent somatic cell hybrids. The results indicate that a gene involved in the expression of the antigen is located on chromosome 10.