阻塞性睡眠呼吸暂停综合征对非肥胖儿童生长发育的影响：双胞胎的平行研究。
The effect of obstructive sleep apnea syndrome on growth and development in nonobese children: a parallel study of twins.
机构信息
Department of Otolaryngology Head and Neck Surgery, Xinhua Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, China.
Department of Otolaryngology Head and Neck Surgery, Xinhua Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, China.
出版信息
J Pediatr. 2015 Mar;166(3):646-50.e1. doi: 10.1016/j.jpeds.2014.11.060.
OBJECTIVE
To explore the effects of obstructive sleep apnea syndrome (OSAS) on children's growth by the study of identical twins.
STUDY DESIGN
Seventeen cases of nonobese children with OSAS were included in this study. The control group was their identical twin sibling, who had no signs of OSAS. Data including height, weight, and serum insulin-like growth factor 1 levels were analyzed before tonsillectomy and adenoidectomy (T&A) and at 3, 6, and 12 months after surgery.
RESULTS
The mean apnea hyponea index was 3.9 times/hour in patients with OSAS and became normal after surgery. Minimum oxygen saturation gradually increased after T&A. The height and weight of the OSAS group before T&A was lower than the control group. During the follow-up period, height and weight increased but were lower than the control group. Serum insulin-like growth factor 1 levels in the OSAS group before T&A were lower than the control group. The level was significantly increased 3 months after T&A.
CONCLUSION
OSAS impairs growth and development. Significant growth recovery occurs after T&A, and early surgical intervention is an important factor for improvement in growth.
目的
通过对同卵双胞胎的研究，探讨阻塞性睡眠呼吸暂停综合征（OSAS）对儿童生长的影响。
研究设计
本研究纳入了 17 例非肥胖 OSAS 患儿。对照组为其无 OSAS 体征的同卵双胞胎。分析了扁桃体切除术和腺样体切除术（T&A）前、术后 3、6 和 12 个月的身高、体重和血清胰岛素样生长因子 1 水平等数据。
结果
OSAS 患者的平均呼吸暂停低通气指数为 3.9 次/小时，术后恢复正常。T&A 后最低血氧饱和度逐渐升高。T&A 前 OSAS 组的身高和体重均低于对照组。在随访期间，身高和体重增加，但仍低于对照组。T&A 前 OSAS 组的血清胰岛素样生长因子 1 水平低于对照组。T&A 后 3 个月水平显著升高。
结论
OSAS 会损害生长发育。T&A 后会出现明显的生长恢复，早期手术干预是改善生长的重要因素。
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