Cadelis G, Ehret N
Service de pneumologie, CHU de Pointe-à-Pitre, 97159 Pointe-à-Pitre cedex, Guadeloupe.
Service de pneumologie, CHU de Pointe-à-Pitre, 97159 Pointe-à-Pitre cedex, Guadeloupe.
Rev Pneumol Clin. 2015 Oct;71(5):301-5. doi: 10.1016/j.pneumo.2014.12.008. Epub 2015 Feb 26.
The coexistence of lung cancer and active tuberculosis is relatively rare. We report a case of concomitant discovery of lung cancer and tuberculosis in the context of addiction to tobacco and cannabis.
A 50-year-old man, smoking tobacco and cannabis since the age of 18, was hospitalized for hemoptysis. Physical examination revealed cachexia, hyperthermia and decreased breath sounds on auscultation of the left lung field. The chest X-ray objectified atelectasis of the left upper lobe. The CT scan revealed a left upper lobe atelectasis and a cavity surrounded opacities taking a tree in bud appearance located at the apex of the left lower lobe. Endoscopy showed an obstruction by a bud located at the upper left lobe. Histology of bronchial biopsy revealed squamous cell carcinoma. Direct examination of bacteriological samples found BAAR and culture confirmed tuberculosis. The contamination could occur via a close relative, smoking cannabis and being treated for tuberculosis. After a 6-month treatment for tuberculosis, the patient underwent a course of chemotherapy, but refused further treatment. Death occurred 3months later.
This observation relates the concomitant discovery of lung cancer and tuberculosis. It also highlights the possible role of cannabis addiction in the transmission of tuberculosis and the occurrence of lung cancer in combination with tobacco.
肺癌与活动性肺结核并存相对罕见。我们报告一例在有烟草和大麻成瘾背景下同时发现肺癌和肺结核的病例。
一名50岁男性,自18岁起吸烟及吸食大麻,因咯血入院。体格检查发现恶病质、高热,左肺野听诊呼吸音减弱。胸部X线显示左上叶肺不张。CT扫描显示左上叶肺不张以及左肺下叶尖部一个呈树芽状的空洞周围实变影。内镜检查显示左肺上叶有肿物阻塞。支气管活检组织学检查显示为鳞状细胞癌。细菌学样本直接检查发现抗酸杆菌,培养证实为肺结核。感染可能通过一名近亲传播,该近亲吸食大麻且正在接受肺结核治疗。经过6个月的抗结核治疗后,患者接受了一个疗程的化疗,但拒绝进一步治疗。3个月后死亡。
本病例报告了肺癌与肺结核的同时发现。它还强调了大麻成瘾在结核病传播以及与烟草共同导致肺癌发生方面可能起到的作用。