腐胺可逆转乌头碱诱导的大鼠心律失常。
Putrescine reverses aconitine-induced arrhythmia in rats.
作者信息
Bazzani C, Genedani S, Tagliavini S, Bertolini A
机构信息
Institute of Pharmacology, University of Modena, Italy.
出版信息
J Pharm Pharmacol. 1989 Sep;41(9):651-3. doi: 10.1111/j.2042-7158.1989.tb06552.x.
Putrescine, (150-300 mg kg-1 i.v.) injected into anaesthetized rats reversed aconitine-induced arrhythmia and restored sinus rhythm. In the same experimental model, quinidine and lignocaine had a transient therapeutic effect, procainamide was practically ineffective and verapamil worsened the aconitine arrhythmia, causing the death of all treated animals. These data demonstrate that putrescine has an antiarrhythmic effect in an experimental model particularly resistant to usual antiarrhythmic treatments.
将腐胺（150 - 300毫克/千克静脉注射）注入麻醉大鼠体内，可逆转乌头碱诱发的心律失常并恢复窦性心律。在同一实验模型中，奎尼丁和利多卡因有短暂的治疗效果，普鲁卡因酰胺几乎无效，而维拉帕米会加重乌头碱引起的心律失常，导致所有接受治疗的动物死亡。这些数据表明，在一个对常规抗心律失常治疗具有特殊抗性的实验模型中，腐胺具有抗心律失常作用。
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