一例经内镜黏膜下剥离术切除的食管内分泌细胞癌合并鳞状细胞癌病例。

A case of endocrine cell carcinoma combined with squamous cell carcinoma of the esophagus resected by endoscopic submucosal dissection.

作者信息

Watanabe Ko, Hikichi Takuto, Sato Masaki, Nakamura Jun, Takagi Tadayuki, Suzuki Rei, Sugimoto Mitsuru, Waragai Yuichi, Kikuchi Hitomi, Konno Naoki, Watanabe Hiroshi, Obara Katsutoshi, Ohira Hiromasa

机构信息

Department of Gastroenterology and Rheumatology School of Medicine, Fukushima Medical University; Department of Endoscopy, Fukushima Medical University Hospital, Japan.

出版信息

Fukushima J Med Sci. 2014;60(2):187-91. doi: 10.5387/fms.2014-2. Epub 2014 Dec 20.

DOI:10.5387/fms.2014-2

PMID:25747609

Abstract

A 55-year-old man with esophageal carcinoma received endoscopic submucosal dissection (ESD) in en-bloc resection. Histopathological examination revealed an admixture of squamous cell carcinoma (SCC) and endocrine cell carcinoma (ECC) with invasion of the deep submucosa. Immunohistochemically, CD 56 and chromogranin A were positive for ECC. Small-cell, medium-cell, and large-cell type ECC were partly surrounded with SCC and partly formed the duct, presenting various patterns. After ESD, he received chemotherapy including CPT-11 plus Cisplatin. He is alive and in good condition today, 55 months after ESD, with no evidence of recurrence.

摘要

一名55岁的食管癌男性患者接受了内镜下黏膜下剥离术（ESD）以完整切除肿瘤。组织病理学检查显示为鳞状细胞癌（SCC）和内分泌细胞癌（ECC）混合存在，侵犯至黏膜下层深部。免疫组化显示，ECC的CD 56和嗜铬粒蛋白A呈阳性。小细胞型、中细胞型和大细胞型ECC部分被SCC包绕，部分形成导管，呈现出多种形态。ESD术后，他接受了包括伊立替康加顺铂的化疗。ESD术后55个月，他目前仍存活且状况良好，无复发迹象。