Mc Auley Mark T, Mooney Kathleen M
Faculty of Science and Engineering, Department of Chemical Engineering, Thornton Science Park, University of Chester, UK.
Faculty of Health and Social Care, Edge Hill University, Ormskirk, Lancashire, UK.
Comput Struct Biotechnol J. 2014 Nov 15;13:38-46. doi: 10.1016/j.csbj.2014.11.006. eCollection 2015.
One of the greatest challenges in biology is to improve the understanding of the mechanisms which underpin aging and how these affect health. The need to better understand aging is amplified by demographic changes, which have caused a gradual increase in the global population of older people. Aging western populations have resulted in a rise in the prevalence of age-related pathologies. Of these diseases, cardiovascular disease is the most common underlying condition in older people. The dysregulation of lipid metabolism due to aging impinges significantly on cardiovascular health. However, the multifaceted nature of lipid metabolism and the complexities of its interaction with aging make it challenging to understand by conventional means. To address this challenge computational modeling, a key component of the systems biology paradigm is being used to study the dynamics of lipid metabolism. This mini-review briefly outlines the key regulators of lipid metabolism, their dysregulation, and how computational modeling is being used to gain an increased insight into this system.
生物学面临的最大挑战之一是加深对衰老背后机制以及这些机制如何影响健康的理解。人口结构变化加剧了更好地理解衰老的必要性，这种变化导致全球老年人口逐渐增加。西方人口老龄化导致与年龄相关的病理状况患病率上升。在这些疾病中，心血管疾病是老年人最常见的潜在病症。衰老导致的脂质代谢失调对心血管健康有重大影响。然而，脂质代谢的多面性及其与衰老相互作用的复杂性使得用传统方法难以理解。为应对这一挑战，作为系统生物学范式关键组成部分的计算建模正被用于研究脂质代谢的动态变化。本综述简要概述了脂质代谢的关键调节因子、它们的失调情况，以及计算建模如何用于更深入了解这一系统。
