来自杜鹃兰的五种新苄基菲类化合物。
Five new benzylphenanthrenes from Cremastra appendiculata.
作者信息
Liu Liang, Li Jun, Zeng Ke-Wu, Jiang Yong, Tu Peng-Fei
机构信息
State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, PR China; Medical College, Yangzhou University, Yangzhou 225009, PR China; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, PR China; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou 225009, PR China.
Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, PR China.
出版信息
Fitoterapia. 2015 Jun;103:27-32. doi: 10.1016/j.fitote.2015.03.003. Epub 2015 Mar 7.
Five new benzylphenanthrenes, cremaphenanthrenes L-P (1-5) were isolated from the EtOAc-soluble extract of the tubers of Cremastra appendiculata. Their structures were elucidated based on the spectroscopic data and chemical methods. Compounds 1-5 were tested in vitro for their cytotoxic effects against colon (HCT-116), cervix (Hela), and breast (MCF-7 and MDA-MB-231) cancer cell lines. Compound 1 showed moderate cytotoxic activities against HCT-116, MCF-7, and MDA-MB-231 cancer cell lines with IC50 values ranging from 15.84 to 24.18 μM and weak cytotoxicity to Hela cell line with IC50 value of 68.81 μM.
从杜鹃兰块茎的乙酸乙酯可溶提取物中分离出五种新的苄基菲类化合物，即杜鹃菲类化合物L - P（1 - 5）。基于光谱数据和化学方法对它们的结构进行了阐明。对化合物1 - 5进行了体外测试，考察其对结肠（HCT - 116）、宫颈（Hela）和乳腺（MCF - 7和MDA - MB - 231）癌细胞系的细胞毒性作用。化合物1对HCT - 116、MCF - 7和MDA - MB - 231癌细胞系表现出中等细胞毒性活性，IC50值范围为15.84至24.18 μM，对Hela细胞系表现出较弱细胞毒性，IC50值为68.81 μM。
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