眼内淋巴瘤的频域光学相干断层扫描模式

Spectral-domain Optical Coherence Tomography Patterns in Intraocular Lymphoma.

作者信息

Keino Hiroshi, Okada Annabelle A, Watanabe Takayo, Echizen Nariaki, Inoue Makoto, Takayama Nobuyuki, Nagane Motoo

机构信息

a Department of Ophthalmology , Kyorin University School of Medicine , Tokyo , Japan .

b Department of Ophthalmology , St. Lukes International Hospital , Tokyo , Japan .

出版信息

Ocul Immunol Inflamm. 2016 Jun;24(3):268-73. doi: 10.3109/09273948.2014.1002568. Epub 2015 Mar 11.

DOI:10.3109/09273948.2014.1002568

PMID:25760916

Abstract

PURPOSE

To examine spectral-domain optical coherence tomography (SD-OCT) patterns in intraocular lymphoma (IOL).

METHODS

Records of 13 patients (21 eyes) with IOL were retrospectively reviewed. SD-OCT was evaluated at initial visit and during follow-up.

RESULTS

SD-OCT images at initial visit demonstrated disruption of the ellipsoid zone (8 eyes, 38.1%) and hyperreflective nodules at the retinal pigment epithelium (RPE) level (5 eyes, 23.8%). During follow-up, disruption of the ellipsoid zone (10 eyes, 47.6%) and hyperreflective nodules at the RPE level (7 eyes, 33.3%) were noted. In 5 eyes showing hyperreflective nodules at the RPE level, the hyperreflective nodules were reduced after treatment with intravitreal methotrexate.

CONCLUSIONS

Hyperreflective nodules in the outer retina and disruption of the ellipsoid zone were observed in nearly one-half of patients with IOL over time. SD-OCT may allow for early detection of small macular abnormalities and aid in monitoring of treatment efficacy in this disease.

摘要

目的

研究眼内淋巴瘤（IOL）的频域光学相干断层扫描（SD - OCT）图像特征。

方法

回顾性分析13例（21只眼）IOL患者的病历资料。在初诊及随访期间进行SD - OCT检查。

结果

初诊时的SD - OCT图像显示椭圆体带破坏（8只眼，38.1%）以及视网膜色素上皮（RPE）层的高反射结节（5只眼，23.8%）。随访期间，观察到椭圆体带破坏（10只眼，47.6%）和RPE层的高反射结节（7只眼，33.3%）。在5只显示RPE层高反射结节的眼中，玻璃体内注射甲氨蝶呤治疗后高反射结节减少。