Yang Weiwei, Lu Zhimin
Key Laboratory of System Biology and Shanghai Key Laboratory of Molecular Andrology, Institute of Biochemistry and Cell Biology, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
Brain Tumor Center and Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA Cancer Biology Program, The University of Texas Graduate School of Biomedical Sciences at Houston, Houston, TX 77030, USA
J Cell Sci. 2015 May 1;128(9):1655-60. doi: 10.1242/jcs.166629. Epub 2015 Mar 13.
Reprogrammed metabolism is a key feature of cancer cells. The pyruvate kinase M2 (PKM2) isoform, which is commonly upregulated in many human cancers, has been recently shown to play a crucial role in metabolism reprogramming, gene transcription and cell cycle progression. In this Cell Science at a glance article and accompanying poster, we provide a brief overview of recent advances in understanding the mechanisms underlying the regulation of PKM2 expression, enzymatic activity, metabolic functions and subcellular location. We highlight the instrumental role of the non-metabolic functions of PKM2 in tumorigenesis and evaluate the potential to target PKM2 for cancer treatment.
代谢重编程是癌细胞的一个关键特征。丙酮酸激酶M2（PKM2）亚型在许多人类癌症中通常上调，最近已被证明在代谢重编程、基因转录和细胞周期进程中起关键作用。在这篇“细胞科学聚焦”文章及随附的海报中，我们简要概述了在理解PKM2表达调控、酶活性、代谢功能和亚细胞定位背后机制方面的最新进展。我们强调了PKM2的非代谢功能在肿瘤发生中的重要作用，并评估了将PKM2作为癌症治疗靶点的潜力。
