Ellis C N, Pennes D R, Martel W, Voorhees J J
Acta Derm Venereol. 1985;65(1):83-5.
Seven patients underwent retrospective radiographic examination 10 to 16 months after high dose isotretinoin therapy for severe cystic acne. One patient, who received the highest isotretinoin dose (approximately twice the average dose taken by the remaining patients), had multiple small hyperostoses of the thoracic spine and tarsi navicular. These findings were identical to the skeletal changes known to occur during retinoid administration. Prospective studies are needed to ascertain the risk of developing hyperostoses during isotretinoin therapy for acne at the lower doses currently employed. In this preliminary study, clinically significant hyperostoses were not a late sequela of high dose isotretinoin treatment for acne.
七名患者在接受高剂量异维甲酸治疗重度囊性痤疮后10至16个月接受了回顾性影像学检查。一名接受了最高异维甲酸剂量（约为其余患者平均剂量的两倍）的患者出现了胸椎和舟状骨的多个小骨增生。这些发现与已知在服用维甲酸期间发生的骨骼变化相同。需要进行前瞻性研究以确定在目前使用的较低剂量异维甲酸治疗痤疮期间发生骨增生的风险。在这项初步研究中，临床上显著的骨增生并非高剂量异维甲酸治疗痤疮的晚期后遗症。
