经颅超声检查及口袋嗅觉测试在帕金森病与特发性震颤鉴别诊断中的应用
Transcranial sonography and the pocket smell test in the differential diagnosis between parkinson's disease and essential tremor.
作者信息
Štenc Bradvica Ivanka, Mihaljević Ivan, Butković-Soldo Silva, Kadojić Dragutin, Titlić Marina, Bradvica Mario, Kralik Kristina
机构信息
Department of Neurology, Faculty of Medicine, Osijek University Hospital, "Josip Juraj Strossmayer" University of Osijek, Osijek, Croatia,
出版信息
Neurol Sci. 2015 Aug;36(8):1403-10. doi: 10.1007/s10072-015-2152-y. Epub 2015 Mar 19.
The aim of this study was to determine the specificity and sensitivity of transcranial sonography (TCS) and the Pocket Smell Test (PST) in differing Parkinson's disease from essential tremor. The results were compared with the dopamin transporter scan (DaTSCAN) findings. Based on the DaTSCAN finding we formed a group of patients with essential tremor (51 patients) and a group with the Parkinson's disease (59 patients). The control group consisted of 26 healthy one. To evaluate the olfactory dysfunction the PST was used, whereas by TCS the substantia nigra hyperechogenicity was marked. The sensitivity and specificity of each diagnostic method was statistically calculated. In confirming Parkinson's disease the specificity of TCS was 88.2 % and the sensitivity 94.9 %. The specificity of PST was 80.4 % whereas the sensitivity was 74.6 %. TCS and PST should be performed to evaluate which patients need to be examined by DaTSCAN.
本研究的目的是确定经颅超声检查（TCS）和简易嗅觉测试（PST）在鉴别帕金森病与特发性震颤方面的特异性和敏感性。将结果与多巴胺转运体扫描（DaTSCAN）的结果进行比较。根据DaTSCAN的结果，我们组建了一组特发性震颤患者（51例）和一组帕金森病患者（59例）。对照组由26名健康人组成。使用PST评估嗅觉功能障碍，而通过TCS标记黑质高回声。对每种诊断方法的敏感性和特异性进行了统计学计算。在确诊帕金森病方面，TCS的特异性为88.2%，敏感性为94.9%。PST的特异性为80.4%，而敏感性为74.6%。应进行TCS和PST检查，以评估哪些患者需要接受DaTSCAN检查。
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