一种用于端粒酶检测的基于单个量子点的生物传感器。

A single quantum dot-based biosensor for telomerase assay.

作者信息

Zhu Guichi, Yang Kun, Zhang Chun-Yang

机构信息

Single-Molecule Detection and Imaging Laboratory, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.

出版信息

Chem Commun (Camb). 2015 Apr 21;51(31):6808-11. doi: 10.1039/c5cc01600b.

DOI:10.1039/c5cc01600b

PMID:25788014

Abstract

Telomerase is a promising biomarker and a therapeutic target due to its extensive expression in human tumors such as lung cancer and breast cancer. Here, we develop a single quantum dot (QD)-based biosensor for the sensitive detection of telomerase activity. This single QD-based biosensor has significant advantages of simplicity and high sensitivity, and it can be applied for the discrimination of tumor cells from normal cells as well as the screening of anticancer drugs.

摘要

端粒酶因其在肺癌和乳腺癌等人类肿瘤中的广泛表达，是一种很有前景的生物标志物和治疗靶点。在此，我们开发了一种基于单量子点（QD）的生物传感器，用于灵敏检测端粒酶活性。这种基于单量子点的生物传感器具有操作简单和灵敏度高的显著优点，可用于区分肿瘤细胞和正常细胞以及抗癌药物的筛选。