饮用水中高氯酸盐与脐血甲状腺激素的关系：来自伊朗的首次经验。
The Relationship between Perchlorate in Drinking Water and Cord Blood Thyroid Hormones: First Experience from Iran.
作者信息
Javidi Ashraf, Rafiei Nasim, Amin Mohammad Mehdi, Hovsepian Silva, Hashemipour Mahin, Kelishadi Roya, Taghian Zahra, Mofateh Samaneh, Poursafa Parinaz
机构信息
Department of Environmental Health Engineering, Environment Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Pediatrics, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran.
出版信息
Int J Prev Med. 2015 Feb 20;6:17. doi: 10.4103/2008-7802.151826. eCollection 2015.
BACKGROUND
Considering the controversial information regarding the effects of perchlorate on thyroid function of high risk population as neonates, and given the high prevalence rate of thyroid disorders specially congenital hypothyroidism in our region, this study aims to investigate for the first time in Iran, the relationship between drinking groundwater perchlorate and cord blood thyroid hormones level in an industrial region.
METHODS
In this cross-sectional study, drinking groundwater perchlorate level of rural areas of Zarinshahr, Isfahan was measured. Simultaneously, cord blood level of thyroid hormones of neonates born in the studied region was measured. Thyroid function test of neonates in regions with low and high perchlorate level were compared.
RESULTS
In this study, 25 tap water samples were obtained for perchlorate measurement. Level of cord blood thyroid stimulating hormone (TSH), T4 and T3 of 25 neonates were measured. Mean (standard deviation) of perchlorate, TSH, T4 and T3 was 3.59 (5.10) μg/l, 7.81 (4.14) mIU/m, 6.06 (0.85) mg/dl, and 63.46 (17.53) mg/dl, respectively. Mean levels of thyroid function tests were not different in low (<5 μg/l) and high level of drinking ground water perchlorate (P > 0.05).
CONCLUSIONS
Perchlorate did not appear to be related to thyroid function of neonates in the studied industrial region. It seems that iodine status of the regions, as well as other environmental contaminants and genetic background, could impact on its relation with thyroid function of neonates.
背景
鉴于关于高氯酸盐对新生儿等高危人群甲状腺功能影响的信息存在争议，且鉴于我们地区甲状腺疾病尤其是先天性甲状腺功能减退症的高患病率，本研究旨在首次在伊朗调查工业区饮用地下水中高氯酸盐与脐血甲状腺激素水平之间的关系。
方法
在这项横断面研究中，对伊斯法罕省扎林沙赫尔农村地区的饮用地下水中高氯酸盐水平进行了测量。同时，测量了研究区域内新生儿的脐血甲状腺激素水平。比较了高氯酸盐水平低和高的地区新生儿的甲状腺功能测试结果。
结果
在本研究中，采集了25份自来水样本用于高氯酸盐测量。测量了25名新生儿的脐血促甲状腺激素（TSH）、T4和T3水平。高氯酸盐、TSH、T4和T3的平均值（标准差）分别为3.59（5.10）μg/l、7.81（4.14）mIU/m、6.06（0.85）mg/dl和63.46（17.53）mg/dl。饮用地下水中高氯酸盐水平低（<5μg/l）和高的地区，甲状腺功能测试的平均水平无差异（P>0.05）。
结论
在研究的工业区，高氯酸盐似乎与新生儿的甲状腺功能无关。该地区的碘状况以及其他环境污染物和遗传背景似乎可能影响其与新生儿甲状腺功能的关系。
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