Tang Yuanyuan, Sinha Debajyoti, Pati Debdeep, Lipsitz Stuart, Lipshultz Steven
Department of Statistics, Florida State University, Tallahassee, FL, USA.
Department of Statistics, Florida State University, Tallahassee, FL, USA
Biostatistics. 2015 Jul;16(3):441-53. doi: 10.1093/biostatistics/kxv005. Epub 2015 Mar 19.
Unlike majority of current statistical models and methods focusing on mean response for highly skewed longitudinal data, we present a novel model for such data accommodating a partially linear median regression function, a skewed error distribution and within subject association structures. We provide theoretical justifications for our methods including asymptotic properties of the posterior and associated semiparametric Bayesian estimators. We also provide simulation studies to investigate the finite sample properties of our methods. Several advantages of our method compared with existing methods are demonstrated via analysis of a cardiotoxicity study of children of HIV-infected mothers.
与当前大多数关注高度偏态纵向数据的均值响应的统计模型和方法不同,我们提出了一种针对此类数据的新模型,该模型包含部分线性中位数回归函数、偏态误差分布和个体内关联结构。我们为我们的方法提供了理论依据,包括后验的渐近性质和相关的半参数贝叶斯估计量。我们还进行了模拟研究,以考察我们方法的有限样本性质。通过对感染艾滋病毒母亲的儿童的心脏毒性研究分析,证明了我们的方法与现有方法相比的几个优点。