RAS驱动型癌症中自噬的转录调控
Transcriptional regulation of autophagy in RAS-driven cancers.
作者信息
Amaravadi Ravi K
出版信息
J Clin Invest. 2015 Apr;125(4):1393-5. doi: 10.1172/JCI81504. Epub 2015 Mar 23.
Abstract
RAS-driven cancers exhibit variable dependency on autophagy for survival; however, it is not fully understood how. In this issue of the JCI, Cheong and colleagues demonstrate that RAS-dependent elevation of casein kinase 1α (CK1α) negatively regulates autophagy at the level of autophagy gene transcription. Moreover, combined inhibition of both CK1α and autophagy reduced proliferation of RAS-driven tumors. The results of this study provide insight into the connection between mutant RAS and autophagy, and suggest targeting CK1α as a potential therapeutic strategy to modulate autophagy in RAS-driven cancers.
摘要
RAS驱动的癌症在生存方面对自噬的依赖程度各不相同；然而，其具体机制尚未完全明确。在本期《临床研究杂志》中，Cheong及其同事证明，RAS依赖的酪蛋白激酶1α（CK1α）水平升高在自噬基因转录水平上对自噬起负调控作用。此外，联合抑制CK1α和自噬可降低RAS驱动肿瘤的增殖。这项研究的结果为深入了解突变型RAS与自噬之间的联系提供了线索，并表明靶向CK1α作为一种潜在的治疗策略，可用于调节RAS驱动癌症中的自噬。
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