将 TGF-β3 掺入胶原-透明质酸支架中可提高其软骨生成潜力。
Incorporation of TGF-beta 3 within collagen-hyaluronic acid scaffolds improves their chondrogenic potential.
机构信息
Tissue Engineering Research Group, Department of Anatomy, Royal College of Surgeons in Ireland, 123 St. Stephen's Green, Dublin 2, Ireland.
Trinity Centre for Bioengineering, Trinity College Dublin, Dublin 2, Ireland.
出版信息
Adv Healthc Mater. 2015 Jun 3;4(8):1175-9. doi: 10.1002/adhm.201500053. Epub 2015 Mar 19.
Incorporation of therapeutics in the form of growth factors within biomaterials can enhance their biofunctionality. Two methods of incorporating transforming growth factor-beta 3 within collagen-hyaluronic acid scaffolds are described, markedly improving mesenchymal stem cell-mediated chondrogenic differentiation and matrix production. Such scaffolds offer control over the release of therapeutics, demonstrating their potential for repair of complex chondral defects requiring additional stimuli.
将生长因子等治疗药物纳入生物材料中，可以增强其生物功能性。本文描述了两种在胶原-透明质酸支架中纳入转化生长因子-β3 的方法，这两种方法显著改善了间充质干细胞介导的软骨分化和基质生成。这些支架可以控制治疗药物的释放，这表明它们具有修复需要额外刺激的复杂软骨缺损的潜力。
Zotero 插件