Kurtz Steven M, Steinbeck Marla, Ianuzzi Allyson, van Ooij André, Punt Ilona M, Isaza Jorge, Ross E R S
Implant Research Center, School of Biomedical Engineering, Science, and Health Systems and Department of Materials Engineering, Drexel University, Philadelphia, PA ; Exponent, Inc., 3401 Market St., Suite 300, Philadelphia, PA.
Implant Research Center, School of Biomedical Engineering, Science, and Health Systems and Department of Materials Engineering, Drexel University, Philadelphia, PA.
SAS J. 2009 Dec 1;3(4):161-77. doi: 10.1016/j.esas.2009.11.003. eCollection 2009.
This article reviews certain practical aspects of retrieval analysis for motion preserving spinal implants and periprosthetic tissues as an essential component of the overall revision strategy for these implants. At our institution, we established an international repository for motion-preserving spine implants in 2004. Our repository is currently open to all spine surgeons, and is intended to be inclusive of all cervical and lumbar implant designs such as artificial discs and posterior dynamic stabilization devices. Although a wide range of alternative materials is being investigated for nonfusion spine implants, many of the examples in this review are drawn from our existing repository of metal-on-polyethylene, metal-on-metal lumbar total disc replacements (TDRs), and polyurethane-based dynamic motion preservation devices. These devices are already approved or nearing approval for use in the United States, and hence are the most clinically relevant at the present time. This article summarizes the current literature on the retrieval analysis of these implants and concludes with recommendations for the development of new test methods that are based on the current state of knowledge of in vivo wear and damage mechanisms. Furthermore, the relevance and need to evaluate the surrounding tissue to obtain a complete understanding of the biological reaction to implant component corrosion and wear is reviewed.
本文回顾了用于保留运动功能的脊柱植入物及假体周围组织的取出分析的某些实际方面,这是这些植入物整体翻修策略的重要组成部分。在我们机构,2004年建立了一个用于保留运动功能的脊柱植入物的国际资料库。我们的资料库目前对所有脊柱外科医生开放,旨在涵盖所有颈椎和腰椎植入物设计,如人工椎间盘和后路动态稳定装置。尽管正在研究多种用于非融合脊柱植入物的替代材料,但本综述中的许多例子都取自我们现有的金属对聚乙烯、金属对金属腰椎全椎间盘置换(TDR)以及基于聚氨酯的动态运动保留装置的资料库。这些装置已获美国批准或即将获批使用,因此是目前临床上最相关的。本文总结了关于这些植入物取出分析的当前文献,并基于体内磨损和损伤机制的现有知识状态,对新测试方法的开发提出了建议。此外,还综述了评估周围组织以全面了解对植入物部件腐蚀和磨损的生物学反应的相关性和必要性。