揭开美国混合人群隐藏的祖先之谜。
Unravelling the hidden ancestry of American admixed populations.
作者信息
Montinaro Francesco, Busby George B J, Pascali Vincenzo L, Myers Simon, Hellenthal Garrett, Capelli Cristian
机构信息
1] Institute of Legal Medicine, Catholic University, Largo F. Vito 1, Rome 00168, Italy [2] Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK.
1] Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK [2] Wellcome Trust Center for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK.
出版信息
Nat Commun. 2015 Mar 24;6:6596. doi: 10.1038/ncomms7596.
The movement of people into the Americas has brought different populations into contact, and contemporary American genomes are the product of a range of complex admixture events. Here we apply a haplotype-based ancestry identification approach to a large set of genome-wide SNP data from a variety of American, European and African populations to determine the contributions of different ancestral populations to the Americas. Our results provide a fine-scale characterization of the source populations, identify a series of novel, previously unreported contributions from Africa and Europe and highlight geohistorical structure in the ancestry of American admixed populations.
人口向美洲的迁移使不同人群相互接触，当代美国人的基因组是一系列复杂混合事件的产物。在这里，我们将基于单倍型的祖先识别方法应用于来自各种美洲、欧洲和非洲人群的大量全基因组SNP数据，以确定不同祖先群体对美洲的贡献。我们的结果提供了源人群的精细特征，识别出一系列来自非洲和欧洲的新的、以前未报告的贡献，并突出了美洲混合人群祖先中的地质历史结构。
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