皮质发育不良大鼠大脑皮层髓鞘纤维变化的定量研究。

A quantitative study on changes of the myelinated fibers in the cerebral cortex of cortical dysplasia rats.

机构信息

Department of Neurology, Affiliated Hospital of Luzhou Medical College, Luzhou 646000, Sichuan Province, China.

Department of Histology and Embryology, Institute of Basic Medical Sciences, Chongqing Medical University, Chongqing 400016, China ; Department of Neurology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.

出版信息

Neural Regen Res. 2012 Feb 5;7(4):268-72. doi: 10.3969/j.issn.1673-5374.2012.04.005.

DOI:10.3969/j.issn.1673-5374.2012.04.005

PMID:25806067

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4353098/

Abstract

An animal model of cortical dysplasia was established through X-ray irradiation induced subcortical heterotopic nodules in rats. Transmission electron microscopy detection of the ultrastructure and the stereology examination showed that there was a significant decrease in cerebral white matter and hippocampal volume, the total volume, volume density, length density and total length of the myelinated fibers in the white matter of cortical dysplasia rats. Subcortical heterotopic nodules of the hippocampal CA1 region and synaptic number density in the CA3 region were reduced compared with normal rats. Our experimental findings indicate that erosed subcortical heterotopic nodules, decreased total length of myelinated nerve fibers and demyelination directly lead to a reduction of white matter volume.

摘要

通过 X 射线照射诱导大鼠皮质下异位结节，建立皮质发育不良动物模型。超微结构透射电镜检测和体视学检查显示，皮质发育不良大鼠脑白质和海马体积明显减少，白质有髓神经纤维的总容积、容积密度、长度密度和总长度均显著降低。与正常大鼠相比，皮质发育不良大鼠海马 CA1 区皮质下异位结节和 CA3 区突触数密度减少。我们的实验结果表明，皮质下异位结节缺失、有髓神经纤维总长度减少和脱髓鞘直接导致白质体积减少。