一种骨骼肌离心收缩中力产生的新型三细丝模型。

Schappacher-Tilp Gudrun, Leonard Timothy, Desch Gertrud, Herzog Walter

Department of Mathematics and Scientific Computing, University of Graz, 8010 Graz, Austria.

Human Performance Laboratory, University of Calgary, Calgary, Alberta, Canada.

PLoS One. 2015 Mar 27;10(3):e0117634. doi: 10.1371/journal.pone.0117634. eCollection 2015.

We propose and examine a three filament model of skeletal muscle force generation, thereby extending classical cross-bridge models by involving titin-actin interaction upon active force production. In regions with optimal actin-myosin overlap, the model does not alter energy and force predictions of cross-bridge models for isometric contractions. However, in contrast to cross-bridge models, the three filament model accurately predicts history-dependent force generation in half sarcomeres for eccentric and concentric contractions, and predicts the activation-dependent forces for stretches beyond actin-myosin filament overlap.

我们提出并研究了一种骨骼肌力量产生的三细丝模型，通过在主动力产生过程中纳入肌联蛋白 - 肌动蛋白相互作用，从而扩展了经典的横桥模型。在肌动蛋白 - 肌球蛋白重叠最佳的区域，该模型对于等长收缩不会改变横桥模型的能量和力量预测。然而，与横桥模型不同的是，三细丝模型能够准确预测半肌节在离心收缩和向心收缩时与历史相关的力量产生，并预测超出肌动蛋白 - 肌球蛋白细丝重叠范围的拉伸时与激活相关的力量。