Wichajarn Khunton, Panamonta Ouyporn, Pradubwong Suteera, Panamonta Manat, Weraarchakul Wiboon, Chowchuen Bowornsilp
J Med Assoc Thai. 2014 Oct;97 Suppl 10:S105-9.
Understanding the genetic etiologies of cleft lip and palate (CLP) is important for improved prevention, treatment, and prognosis for patients affected by CLP.
To report the prevalence and the type of associated syndromes in Northeastern Thai patients with CLP.
A retrospective study of123 cleft lip/palate children aged 4-5 years was carried out at the Tawanchai Cleft Centel; Khon Kaen University during the period from October to December 2011. Data were collected by reviewing the patient 's medical records.
Seventeen (14%) of the 123 children had multiple malformations and five (4%) of these children had associated syndromes. Syndromes were identified in 5 (29%) of the 17 children who had associated malformations. The syndromes were Apert, Cleft lip/palate-ectodermal dysplasia, Kabuki, Oculo-Auriculo-Vertebral Spectrum, and Velocardiofacial syndrome.
Recognition of the associated syndrome in a patient with CLP is essential to assess the problem of the patient, provide necessaty treatment and the appropriate methodology of prevention.
了解唇腭裂（CLP）的遗传病因对于改善受CLP影响患者的预防、治疗和预后非常重要。
报告泰国东北部CLP患者相关综合征的患病率和类型。
2011年10月至12月期间，在孔敬大学Tawanchai腭裂中心对123名4 - 5岁的唇腭裂儿童进行了回顾性研究。通过查阅患者病历收集数据。
123名儿童中有17名（14%）患有多种畸形，其中5名（4%）儿童患有相关综合征。在17名患有相关畸形的儿童中，有5名（29%）被确诊患有综合征。这些综合征分别是阿佩尔综合征、唇腭裂 - 外胚层发育不良、歌舞伎综合征、眼耳脊椎综合征和腭心面综合征。
识别CLP患者的相关综合征对于评估患者问题、提供必要治疗和适当的预防方法至关重要。
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