动态巩膜：正常眼生长和近视发展中的细胞外基质重塑
The dynamic sclera: extracellular matrix remodeling in normal ocular growth and myopia development.
作者信息
Harper Angelica R, Summers Jody A
机构信息
Department of Cell Biology, University of Oklahoma Health Science Center, Oklahoma City, OK, USA.
Department of Cell Biology, University of Oklahoma Health Science Center, Oklahoma City, OK, USA.
出版信息
Exp Eye Res. 2015 Apr;133:100-11. doi: 10.1016/j.exer.2014.07.015.
Abstract
Myopia is a common ocular condition, characterized by excessive elongation of the ocular globe. The prevalence of myopia continues to increase, particularly among highly educated groups, now exceeding 80% in some groups. In parallel with the increased prevalence of myopia, are increases in associated blinding ocular conditions including glaucoma, retinal detachment and macular degeneration, making myopia a significant global health concern. The elongation of the eye is closely related to the biomechanical properties of the sclera, which in turn are largely dependent on the composition of the scleral extracellular matrix. Therefore an understanding of the cellular and extracellular events involved in the regulation of scleral growth and remodeling during childhood and young adulthood will provide future avenues for the treatment of myopia and its associated ocular complications.
摘要
近视是一种常见的眼部疾病，其特征是眼球过度伸长。近视的患病率持续上升，尤其是在高学历人群中，现在某些群体中的患病率超过了80%。与近视患病率上升同时出现的是，包括青光眼、视网膜脱离和黄斑变性在内的相关致盲性眼部疾病也在增加，这使得近视成为一个重大的全球健康问题。眼球的伸长与巩膜的生物力学特性密切相关，而巩膜的生物力学特性又在很大程度上取决于巩膜细胞外基质的组成。因此，了解儿童和青年时期巩膜生长和重塑调节过程中涉及的细胞和细胞外事件，将为未来治疗近视及其相关眼部并发症提供途径。
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