Vázquez-Del Mercado Mónica, Nuñez-Atahualpa Lourdes, Figueroa-Sánchez Mauricio, Gómez-Bañuelos Eduardo, Rocha-Muñoz Alberto Daniel, Martín-Márquez Beatriz Teresita, Corona-Sanchez Esther Guadalupe, Martínez-García Erika Aurora, Macias-Reyes Héctor, Gonzalez-Lopez Laura, Gamez-Nava Jorge Ivan, Navarro-Hernandez Rosa Elena, Nuñez-Atahualpa María Alejandra, Andrade-Garduño Javier
Instituto de Investigación en Reumatología y del Sistema Músculo Esquelético, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada No. 950, Colonia Independencia, 44340 Guadalajara, JAL, Mexico ; Departamento de Reumatología, Hospital Civil "Dr. Juan I. Menchaca", Universidad de Guadalajara, Salvador de Quevedo No. 750, 44100 Guadalajara, JAL, Mexico.
Hospital Civil de Guadalajara "Fray Antonio Alcalde", Universidad de Guadalajara, Hospital No. 278, 44280 Guadalajara, JAL, Mexico.
Biomed Res Int. 2015;2015:342649. doi: 10.1155/2015/342649. Epub 2015 Mar 2.
The main cause of death in rheumatoid arthritis (RA) is cardiovascular events. We evaluated the relationship of anticyclic citrullinated peptide (anti-CCP) antibody levels with increased carotid intima-media thickness (cIMT) in RA patients.
Forty-five anti-CCP positive and 37 anti-CCP negative RA patients, and 62 healthy controls (HC) were studied. All groups were assessed for atherogenic index of plasma (AIP) and cIMT. Anti-CCP, C-reactive protein (CRP), and levels of tumor necrosis factor alpha (TNFα) and interleukin-6 (IL-6) were measured by enzyme-linked immunosorbent assay (ELISA).
The anti-CCP positive RA patients showed increased cIMT compared to HC and anti-CCP negative (P < 0.001). Anti-CCP positive versus anti-CCP negative RA patients, had increased AIP, TNFα and IL-6 (P < 0.01), and lower levels of high density lipoprotein cholesterol (HDL-c) (P = 0.02). The cIMT correlated with levels of anti-CCP (r = 0.513, P = 0.001), CRP (r = 0.799, P < 0.001), TNFα (r = 0.642, P = 0.001), and IL-6 (r = 0.751, P < 0.001). In multiple regression analysis, cIMT was associated with CRP (P < 0.001) and anti-CCP levels (P = 0.03).
Levels of anti-CCP and CRP are associated with increased cIMT and cardiovascular risk supporting a clinical role of the measurement of cIMT in RA in predicting and preventing cardiovascular events.
类风湿关节炎（RA）的主要死因是心血管事件。我们评估了RA患者中抗环瓜氨酸肽（抗CCP）抗体水平与颈动脉内膜中层厚度（cIMT）增加之间的关系。
研究了45例抗CCP阳性和37例抗CCP阴性的RA患者以及62例健康对照（HC）。对所有组评估血浆致动脉粥样硬化指数（AIP）和cIMT。通过酶联免疫吸附测定（ELISA）测量抗CCP、C反应蛋白（CRP）以及肿瘤坏死因子α（TNFα）和白细胞介素-6（IL-6）的水平。
与HC和抗CCP阴性患者相比，抗CCP阳性的RA患者cIMT增加（P < 0.001）。抗CCP阳性的RA患者与抗CCP阴性的RA患者相比，AIP、TNFα和IL-6增加（P < 0.01），高密度脂蛋白胆固醇（HDL-c）水平降低（P = 0.02）。cIMT与抗CCP水平（r = 0.513，P = 0.001）、CRP（r = 0.799，P < 0.001）、TNFα（r = 0.642，P = 0.001）和IL-6（r = 0.751，P < 0.001）相关。在多元回归分析中，cIMT与CRP（P < 0.001）和抗CCP水平（P = 0.03）相关。
抗CCP和CRP水平与cIMT增加和心血管风险相关，支持在RA中测量cIMT在预测和预防心血管事件方面的临床作用。
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