进化与传染病中的五个挑战。
Five challenges in evolution and infectious diseases.
作者信息
Metcalf C J E, Birger R B, Funk S, Kouyos R D, Lloyd-Smith J O, Jansen V A A
机构信息
Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ, USA; Division of Epidemiology and Population Studies, Fogarty International Center, National Institutes of Health, Bethesda, MD, USA.
Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ, USA.
出版信息
Epidemics. 2015 Mar;10:40-4. doi: 10.1016/j.epidem.2014.12.003. Epub 2014 Dec 18.
Evolution is a key aspect of the biology of many pathogens, driving processes ranging from immune escape to changes in virulence. Because evolution is inherently subject to feedbacks, and because pathogen evolution plays out at scales ranging from within-host to between-host and beyond, evolutionary questions provide special challenges to the modelling community. In this article, we provide an overview of five challenges in modelling the evolution of pathogens and their hosts, and point to areas for development, focussing in particular on the issue of linking theory and data.
进化是许多病原体生物学的一个关键方面，推动着从免疫逃逸到毒力变化等一系列过程。由于进化本质上会受到反馈的影响，且病原体进化在从宿主内部到宿主之间及更广泛的尺度上发生，进化问题给建模界带来了特殊挑战。在本文中，我们概述了病原体及其宿主进化建模中的五个挑战，并指出了发展领域，特别关注理论与数据的联系问题。
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