Yu Xiaohua, Tang Xiaoyan, Gohil Shalini V, Laurencin Cato T
Institute for Regenerative Engineering, University of Connecticut Health Center, Farmington, CT, 06030, USA.
The Raymond and Beverly Sackler Center for Biomedical Biological, Physical and Engineering Sciences, University of Connecticut Health Center, Farmington, CT, 06030, USA.
Adv Healthc Mater. 2015 Jun 24;4(9):1268-85. doi: 10.1002/adhm.201400760. Epub 2015 Apr 7.
Strategies for bone tissue regeneration have been continuously evolving for the last 25 years since the introduction of the "tissue engineering" concept. The convergence of the life, physical, and engineering sciences has brought in several advanced technologies available to tissue engineers and scientists. This resulted in the creation of a new multidisciplinary field termed as "regenerative engineering". In this article, the role of biomaterials in bone regenerative engineering is systematically reviewed to elucidate the new design criteria for the next generation of biomaterials for bone regenerative engineering. The exemplary design of biomaterials harnessing various materials characteristics towards successful bone defect repair and regeneration is highlighted. Particular attention is given to the attempts of incorporating advanced materials science, stem cell technologies, and developmental biology into biomaterials design to engineer and develop the next generation bone grafts.
自“组织工程”概念引入以来的过去25年里,骨组织再生策略一直在不断发展。生命科学、物理科学和工程科学的融合为组织工程师和科学家带来了多种先进技术。这催生了一个名为“再生工程”的新多学科领域。在本文中,系统回顾了生物材料在骨再生工程中的作用,以阐明骨再生工程下一代生物材料的新设计标准。重点介绍了利用各种材料特性实现成功骨缺损修复和再生的生物材料的典型设计。特别关注将先进材料科学、干细胞技术和发育生物学纳入生物材料设计以设计和开发下一代骨移植材料的尝试。