用光学相干断层扫描和漫反射光谱研究二氧化钛纳米颗粒与二极管激光联合作用对体外正常人肺组织和癌性肺组织光学特性的影响。
Effects of titanium dioxide nanoparticles coupled with diode laser on optical properties of in vitro normal and cancerous human lung tissues studied with optical coherence tomography and diffuse reflectance spectra.
作者信息
Zhou Lianpeng, Wu Guoyong, Wei Huajiang, Guo Zhouyi, Yang Hongqin, He Yonghong, Xie Shusen, Liu Ying, Meng Qingan
机构信息
South China Normal University, College of Biophotonics, MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, 55 Zhongshan Road, Guangzhou, Guangdong Province 510631, China.
Sun Yat-Sen University, the First Affiliated Hospital, Department of Surgery, 58 Zhongshan 2 Road, Guangzhou, Guangdong Province 510080, China.
出版信息
J Biomed Opt. 2015 Apr;20(4):046003. doi: 10.1117/1.JBO.20.4.046003.
The objective is to investigate the effects of two different sized (60 and 100 nm) titanium dioxide (TiO2) nanoparticles (NPs) penetration and accumulation in in vitro human normal lung (NL) tissue, lung squamous cell carcinoma (LSCC) tissue, and 650-nm diode laser-pretreated tissue on their optical properties studied with optical coherence tomography monitoring and diffuse reflectance (DR) spectra measurement. As with TiO2 NPs penetrating into the tissues, the intensities of DR of the samples increase, and then the enhancements of DR and the attenuation coefficients of the tissues were quantitatively calculated. The results suggest that 650-nm diode laser pretreatment increased the amounts of TiO2 NPs penetration and accumulation in NL and LSCC tissues, and the tissue optical properties were significantly influenced by accumulation of TiO2 NPs.
目的是研究两种不同尺寸（60和100纳米）的二氧化钛（TiO2）纳米颗粒（NPs）在体外人正常肺（NL）组织、肺鳞状细胞癌（LSCC）组织以及经650纳米二极管激光预处理的组织中的渗透和积累情况，以及通过光学相干断层扫描监测和漫反射（DR）光谱测量对其光学特性的影响。随着TiO2 NPs渗透到组织中，样品的DR强度增加，然后定量计算DR的增强和组织的衰减系数。结果表明，650纳米二极管激光预处理增加了TiO2 NPs在NL和LSCC组织中的渗透和积累量，并且组织光学特性受到TiO2 NPs积累的显著影响。
Zotero 插件