Saitoh Y, Arita N, Hayakawa T, Nakao K, Mogami H
Department of Neurosurgery, Osaka University Medical School, Japan.
Neurosurgery. 1989 Nov;25(5):820-3. doi: 10.1097/00006123-198911000-00022.
A 21-year-old man with an oligodendroglioma in the anterior horn of the right lateral ventricle complained of sexual dysfunction and showed lowered concentrations of serum testosterone (1.1 ng/ml) with normal pituitary function. Human chorionic gonadotropin testing revealed a good testosterone response (1.1 to 4.9 ng/ml) and a clomiphene test revealed no gonadotropin response. Pulsatile secretion of luteinizing hormone (LH) was absent preoperatively. After removal of the tumor, serum concentration of testosterone increased to the normal range, LH pulsatility appeared, and the patient had no complaints of sexual dysfunction. In this patient, the loss of LH pulsatility responsible for his hypogonadism was caused by the lateral ventricle tumor compressing the surrounding structures, and this was corrected by tumor resection.
一名21岁男性，右侧脑室前角患有少突胶质细胞瘤，主诉性功能障碍，血清睾酮浓度降低（1.1 ng/ml），垂体功能正常。人绒毛膜促性腺激素检测显示睾酮反应良好（从1.1 ng/ml升至4.9 ng/ml），克罗米芬试验显示无促性腺激素反应。术前促黄体生成素（LH）无脉冲式分泌。肿瘤切除后，血清睾酮浓度升至正常范围，LH出现脉冲式分泌，患者性功能障碍症状消失。该患者性腺功能减退所致的LH脉冲式分泌缺失是由侧脑室肿瘤压迫周围结构引起的，肿瘤切除后得以纠正。
