新生儿单纯疱疹病毒感染的死亡率。
The mortality of neonatal herpes simplex virus infection.
作者信息
Lopez-Medina Eduardo, Cantey Joseph B, Sánchez Pablo J
机构信息
Department of Pediatrics, Universidad del Valle, Cali, Colombia; Centro de Estudios en Infectología Pediátrica, Cali, Colombia.
Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX.
出版信息
J Pediatr. 2015 Jun;166(6):1529-32.e1. doi: 10.1016/j.jpeds.2015.03.004. Epub 2015 Apr 11.
This retrospective study characterized the clinical course of 13 neonates who died with herpes simplex virus infection from 2001 to 2011, representing a 26% case-fatality rate. Fatal disease developed at ≤ 48 hours of age in one-third of infants, was mostly disseminated disease, and occurred despite early administration of high-dose acyclovir therapy.
这项回顾性研究描述了2001年至2011年间13例死于单纯疱疹病毒感染的新生儿的临床病程，病死率为26%。三分之一的婴儿在出生后48小时内病情恶化，多数为播散性疾病，尽管早期给予了大剂量阿昔洛韦治疗，但仍发生了致命疾病。
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