中国北方自然发生的传染性法氏囊病病毒重配株
Naturally occurring reassortant infectious bursal disease virus in northern China.
作者信息
Lu Zhen, Zhang Lizhou, Wang Nian, Chen Yuming, Gao Li, Wang Yongqiang, Gao Honglei, Gao Yulong, Li Kai, Qi Xiaole, Wang Xiaomei
机构信息
Division of Avian Infectious Diseases, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, the Chinese Academy of Agricultural Sciences, Harbin 150001, PR China.
Division of Avian Infectious Diseases, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, the Chinese Academy of Agricultural Sciences, Harbin 150001, PR China; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Disease and Zoonoses, Yangzhou 225009, PR China.
出版信息
Virus Res. 2015 May 4;203:92-5. doi: 10.1016/j.virusres.2015.04.003. Epub 2015 Apr 11.
Infectious bursal disease virus (IBDV) is a bi-segmented, double-stranded RNA virus that belongs to the genus Avibirnavirus of the family of Birnavirideae. The co-evolution of genome segments is a major evolutionary feature for IBDV. However, in recent years, some strains exhibited markedly different genetic relationships for segments A and B. In this study, we firstly isolated a new type of reassortment IBDV strain named IBD13HeB01 from northern China. The full-length genomes of segments A and B were cloned and identified. Sequence analysis revealed that IBD13HeB01 was a segment-reassortment strain, whose segment A was derived from very virulent strain and segment B from attenuated IBDV. In addition, the virulence of IBD13HeB01 strain was evaluated using SPF chickens. This study is not only beneficial for further understanding of the viral evolution but also suggests the potential risk of application of the live vaccines of IBDV.
传染性法氏囊病病毒（IBDV）是一种双节段双链RNA病毒，属于双RNA病毒科禽双RNA病毒属。基因组片段的共同进化是IBDV的主要进化特征。然而，近年来，一些毒株的A和B片段呈现出明显不同的遗传关系。在本研究中，我们首先从中国北方分离出一种新型重配IBDV毒株，命名为IBD13HeB01。克隆并鉴定了A和B片段的全长基因组。序列分析表明，IBD13HeB01是一个片段重配毒株，其A片段来源于超强毒株，B片段来源于弱毒IBDV。此外，使用SPF鸡评估了IBD13HeB01毒株的毒力。本研究不仅有助于进一步了解病毒进化，还提示了IBDV活疫苗应用的潜在风险。
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