Hartman Alan R, Manetta Frank, Lessen Ronald, Pekmezaris Renee, Kozikowski Andrzej, Jahn Lynda, Akerman Meredith, Lesser Martin L, Glassman Lawrence R, Graver Michael, Scheinerman Jacob S, Kalimi Robert, Palazzo Robert, Vatsia Sheel, Pogo Gustave, Hall Michael, Yu Pey-Jen, Singh Vijay
Tex Heart Inst J. 2015 Feb 1;42(1):25-9. doi: 10.14503/THIJ-13-3877. eCollection 2015 Feb.
Acute pulmonary embolism is a substantial cause of morbidity and death. Although the American College of Chest Physicians Evidence-Based Clinical Practice Guidelines recommend surgical pulmonary embolectomy in patients with acute pulmonary embolism associated with hypotension, there are few reports of 30-day mortality rates. We performed a retrospective review of acute pulmonary embolectomy procedures performed in 96 consecutive patients who had severe, globally hypokinetic right ventricular dysfunction as determined by transthoracic echocardiography. Data on patients who were treated from January 2003 through December 2011 were derived from health system databases of the New York State Cardiac Surgery Reporting System and the Society of Thoracic Surgeons. The data represent procedures performed at 3 tertiary care facilities within a large health system operating in the New York City metropolitan area. The overall 30-day mortality rate was 4.2%. Most patients (68 [73.9%]) were discharged home or to rehabilitation facilities (23 [25%]). Hemodynamically stable patients with severe, globally hypokinetic right ventricular dysfunction had a 30-day mortality rate of 1.4%, with a postoperative mean length of stay of 9.1 days. Comparable findings for hemodynamically unstable patients were 12.5% and 13.4 days, respectively. Acute pulmonary embolectomy can be a viable procedure for patients with severe, globally hypokinetic right ventricular dysfunction, with or without hemodynamic compromise; however, caution is warranted. Our outcomes might be dependent upon institutional capability, experience, surgical ability, and careful patient selection.
急性肺栓塞是发病和死亡的重要原因。尽管美国胸科医师学会循证临床实践指南推荐对伴有低血压的急性肺栓塞患者行外科肺动脉血栓切除术,但关于30天死亡率的报道较少。我们对连续96例行急性肺动脉血栓切除术的患者进行了回顾性研究,这些患者经经胸超声心动图检查确定存在严重的、整体运动减弱的右心室功能障碍。2003年1月至2011年12月接受治疗的患者数据来自纽约州心脏外科报告系统和胸外科医师协会的卫生系统数据库。这些数据代表了在纽约市大都市区一个大型卫生系统内的3家三级医疗设施所进行的手术。总体30天死亡率为4.2%。大多数患者(68例[73.9%])出院回家或转至康复机构(23例[25%])。血流动力学稳定的严重、整体运动减弱的右心室功能障碍患者30天死亡率为1.4%,术后平均住院时间为9.1天。血流动力学不稳定患者的相应结果分别为12.5%和13.4天。对于有或无血流动力学损害的严重、整体运动减弱的右心室功能障碍患者,急性肺动脉血栓切除术可能是一种可行的手术;然而,仍需谨慎。我们的结果可能取决于机构能力、经验、手术能力和仔细的患者选择。