角膜基质营养不良的角膜地形图分析
Corneal topography analysis of stromal corneal dystrophies.
作者信息
Kocluk Yusuf, Yalniz-Akkaya Zuleyha, Burcu Ayse, Ornek Firdevs
机构信息
Yusuf Kocluk, MD, Ophthalmolgy Clinic, Ministry of Health, Adana Numune Training and Research Hospital, TR01076, Adana, Turkey.
Zuleyha Yalniz-Akkaya, MD, Ophthalmolgy Clinic, Ministry of Health, Ankara Training and Research Hospital, TR06340 Ankara, Turkey.
出版信息
Pak J Med Sci. 2015 Jan-Feb;31(1):116-20. doi: 10.12669/pjms.311.6292.
OBJECTIVE
The aim was to compare the corneal topography and tomography parameters of macular corneal dystrophy (MCD), granular corneal dystrophy (GCD) and lattice corneal dystrophy (LCD) patients obtained by Scheimpflug imaging system.
METHODS
The charts, photographs and topography images of patients were reviewed retrospectively. This study included 73 eyes of 73 patients (28 MCD, 20 GCG and 25 LCD patients). Topography images were obtained by Pentacam (Oculus Optikgerate, Wetzlar, Germany). The densitometry readings at the corneal apex were used for the statistics.
RESULTS
The female to male ratio was 13/15 in MCD group, 12/8 in GCD group and 13/12 in LCD group. The mean age median age was 32, 45 and 53 years in MCD, GCD and LCD groups respectively. The groups were similar regarding the gender (p=0.861). The MCD group was significantly younger than the other two groups (p<0.001). The median (minmum-maximum) corneal densities were 100 (100-100), 68 (17-100) and 97 (34-100) Pentacam densitometry units in MCD, GCD and LCD groups respectively. The corneal density at the corneal apex was significantly higher in MCD group than in the other groups (p<0.001). The GCD and LCD groups were statistically similar in terms of density of the corneal apex (p=0.079). In MCD group, corneal thickness at the apex and at the thinnest location was significantly thinner, than in the other groups (p=.002 for thickness at apex between MCD and LCD, and p<.001 for all the remaining comparisons). In MCD group corneal volume was significantly smaller than in the other groups (p<.001 for all comparisons).
CONCLUSION
Densitometry on Scheimpflug imaging system gives information on the density of corneal opacities.
目的
比较通过Scheimpflug成像系统获得的黄斑角膜营养不良（MCD）、颗粒状角膜营养不良（GCD）和格子状角膜营养不良（LCD）患者的角膜地形图和断层扫描参数。
方法
回顾性分析患者的病历、照片和地形图图像。本研究纳入了73例患者的73只眼（28例MCD患者、20例GCG患者和25例LCD患者）。通过Pentacam（德国韦茨拉尔的Oculus Optikgerate公司）获取地形图图像。使用角膜顶点的密度测量读数进行统计分析。
结果
MCD组的男女比例为13/15，GCD组为12/8，LCD组为13/12。MCD、GCD和LCD组的平均年龄中位数分别为32岁、45岁和53岁。各组在性别方面相似（p = 0.861）。MCD组明显比其他两组年轻（p < 0.001）。MCD、GCD和LCD组的角膜密度中位数（最小值 - 最大值）分别为100（100 - 100）、68（17 - 100）和97（34 - 100）Pentacam密度测量单位。MCD组角膜顶点的角膜密度明显高于其他组（p < 0.001）。GCD组和LCD组在角膜顶点密度方面在统计学上相似（p = 0.079）。在MCD组中，顶点和最薄处的角膜厚度明显比其他组薄（MCD与LCD之间顶点厚度的p值为0.002，其余所有比较的p值均<0.001）。MCD组的角膜体积明显小于其他组（所有比较的p值均<0.001）。
结论
Scheimpflug成像系统上的密度测量可提供有关角膜混浊密度的信息。
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