抗基底节抗体与 ADHD 中的链球菌感染。
Anti-Basal Ganglia Antibodies and Streptococcal Infection in ADHD.
机构信息
1 Navarra Health Service Hospital, Pamplona, Spain.
2 Clínica Universidad de Navarra, Pamplona, Spain.
出版信息
J Atten Disord. 2018 Jul;22(9):864-871. doi: 10.1177/1087054715580841. Epub 2015 Apr 16.
OBJECTIVE
Group A Streptococcus has been associated with ADHD, tic disorders (TD), and obsessive-compulsive disorder (OCD) through anti-basal ganglia antibodies (ABGA).
METHOD
We investigated the association between ABGA and streptococcal exposure with behavioral, motor, and cognitive measures in 38 children with ADHD not comorbid to OCD or TD (nc-ADHD) and in 38 healthy children. An additional group of 15 children with TD and/or OCD was examined.
RESULTS
ABGA titers were present in 3% of nc-ADHD patients and controls but in 27% of TD and/or OCD patients. Evidence of streptococcal exposure was similar between ADHD patients and controls living in the same urban area. Behavioral, motor, and cognitive measures were not associated with anti-streptococcal antibodies.
CONCLUSION
ABGA do not distinguish nc-ADHD from controls. The differences in the frequency of streptococcal exposure in previous studies are determined by the dynamic nature of the infection rather than the behavioral phenotype of ADHD.
目的
通过抗基底神经节抗体 (ABGA)，A 组链球菌与注意力缺陷多动障碍 (ADHD)、抽动障碍 (TD) 和强迫症 (OCD) 有关。
方法
我们通过行为、运动和认知测量，调查了 38 名无 OCD 或 TD 共病的 ADHD 儿童 (nc-ADHD) 和 38 名健康儿童中 ABGA 与链球菌暴露之间的关联。还检查了 15 名患有 TD 和/或 OCD 的儿童。
结果
nc-ADHD 患者和对照组中 ABGA 滴度分别为 3%和 3%，但 TD 和/或 OCD 患者中 ABGA 滴度为 27%。生活在同一城市地区的 ADHD 患者和对照组的链球菌暴露证据相似。行为、运动和认知测量与抗链球菌抗体无关。
结论
ABGA 无法将 nc-ADHD 与对照组区分开来。以前研究中链球菌暴露频率的差异是由感染的动态性质决定的，而不是 ADHD 的行为表型。
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