用稳定二氧化氯对耐过氧化氢的细菌芽孢进行灭菌
Sterilization of hydrogen peroxide resistant bacterial spores with stabilized chlorine dioxide.
作者信息
Friedline Anthony, Zachariah Malcolm, Middaugh Amy, Heiser Matt, Khanna Neeraj, Vaishampayan Parag, Rice Charles V
机构信息
Department of Chemistry and Biochemistry, Stephenson Life Sciences Research Center, University of Oklahoma, Norman, Oklahoma USA.
Bio-Cide International, Inc., Norman, Oklahoma USA.
出版信息
AMB Express. 2015 Apr 17;5:24. doi: 10.1186/s13568-015-0109-4. eCollection 2015.
Bacillus pumilus SAFR-032 spores isolated from a clean room environment are known to exhibit enhanced resistance to peroxide, desiccation, UV radiation and chemical disinfection than other spore-forming bacteria. The survival of B. pumilus SAFR-032 spores to standard clean room sterilization practices requires development of more stringent disinfection agents. Here, we report the effects of a stabilized chlorine dioxide-based biocidal agent against spores of B. pumilus SAFR-032 and Bacillus subtilis ATCC 6051. Viability was determined via CFU measurement after exposure. Chlorine dioxide demonstrated efficacy towards sterilization of spores of B. pumilus SAFR-032 equivalent or better than exposure to hydrogen peroxide. These results indicate efficacy of chlorine dioxide delivered through a stabilized chlorine dioxide product as a means of sterilization of peroxide- and UV-resistant spores.
从洁净室环境中分离出的短小芽孢杆菌SAFR-032孢子，相较于其他形成孢子的细菌，已知其对过氧化物、干燥、紫外线辐射和化学消毒具有更强的抗性。短小芽孢杆菌SAFR-032孢子在标准洁净室灭菌操作下的存活，需要开发更严格的消毒剂。在此，我们报告了一种基于稳定二氧化氯的杀菌剂对短小芽孢杆菌SAFR-032和枯草芽孢杆菌ATCC 6051孢子的影响。暴露后通过CFU测量确定活力。二氧化氯对短小芽孢杆菌SAFR-032孢子的灭菌效果等同于或优于过氧化氢处理。这些结果表明，通过稳定二氧化氯产品提供的二氧化氯作为一种对过氧化物和紫外线具有抗性的孢子的灭菌手段是有效的。
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