α1B-糖蛋白（A1BG）与路德（LU）血型系统之间的连锁关系：定位于19号染色体：A1BG的新遗传变异体。

Linkage between alpha 1B-glycoprotein (A1BG) and Lutheran (LU) red blood group system: assignment to chromosome 19: new genetic variants of A1BG.

作者信息

Eiberg H, Bisgaard M L, Mohr J

机构信息

University Institute of Medical Genetics, Copenhagen, Denmark.

出版信息

Clin Genet. 1989 Dec;36(6):415-8.

PMID:2591067

Abstract

alpha 1B-glycoprotein (A1BG) polymorphism was examined in a Danish family material (no. 604-1505) with particular regard to markers on chromosome 19. For A1BG-LU we found a lod score z = 3.06 at theta = 0.05 in males, and z = 1.42 at theta = 0.10 in females, which assigns A1BG to chromosome 19. Close linkage to C3, SE, PEPD, APOC2, D19S7, D19S8 and D19S9 was excluded. The most likely order would appear to be C3-SE-LU-A1BG.

摘要

在一个丹麦家系材料（编号604 - 1505）中研究了α1B - 糖蛋白（A1BG）多态性，特别关注19号染色体上的标记。对于A1BG - LU，我们在男性中发现，在θ = 0.05时连锁值z = 3.06，在女性中，在θ = 0.10时z = 1.42，这将A1BG定位于19号染色体。排除了与C3、SE、PEPD、APOC2、D19S7、D19S8和D19S9的紧密连锁。最可能的顺序似乎是C3 - SE - LU - A1BG。