Dean Heather J, Sellers Elizabeth A C
Department of Pediatrics and Child Health, College of Medicine, Faculty of Health Sciences, University of Manitoba, Winnipeg, MB R3E 0Z2, Canada.
Biochem Cell Biol. 2015 Oct;93(5):425-9. doi: 10.1139/bcb-2014-0152. Epub 2015 Feb 5.
Prior to 1985, type 2 diabetes was a disease of adults. Simultaneously with the global epidemic of childhood obesity, type 2 diabetes has increased in children. Initially, the presentation of small case series of type 2 diabetes in children was met with skepticism. As the number and size of the case series grew and the first long-term outcomes of end-stage complications in young adults appeared in the literature, the international community took notice with guarded interest. Type 2 diabetes disproportionately affects the children of specific ethnic groups and from disadvantaged socioeconomic environments, especially Indigenous populations. The past decade has seen unprecedented intense global interest in the etiology, treatment, and prevention of type 2 diabetes in children.
1985年以前,2型糖尿病是一种成人疾病。随着儿童肥胖症在全球的流行,儿童2型糖尿病的发病率也在上升。最初,儿童2型糖尿病的小病例系列报告遭到了质疑。随着病例系列的数量和规模不断增加,以及关于年轻成人终末期并发症的首批长期研究结果在文献中出现,国际社会开始关注并持谨慎态度。2型糖尿病对特定种族以及社会经济环境不利的儿童影响尤为严重,特别是原住民。在过去十年中,全球对儿童2型糖尿病的病因、治疗和预防产生了前所未有的浓厚兴趣。