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糖尿病筛查:高血压/肥胖患者中一个悬而未决的问题。

Diabetes screening: a pending issue in hypertense/obese patients.

作者信息

Sepehri Armina, Palazón-Bru Antonio, Gil-Guillén Vicente Francisco, Ramírez-Prado Dolores, Navarro-Cremades Felipe, Cortés Ernesto, Rizo-Baeza María Mercedes

机构信息

Department of Clinical Medicine, Miguel Hernández University , San Juan de Alicante, Alicante , Spain.

Department of Pharmacology, Paediatrics and Organic Chemistry, Miguel Hernández University , San Juan de Alicante, Alicante , Spain.

出版信息

PeerJ. 2015 Apr 23;3:e914. doi: 10.7717/peerj.914. eCollection 2015.

Abstract

The literature about possible cardiovascular consequences of diagnostic inertia in diabetes is scarce. We examined the influence of undetected high fasting blood glucose (FBG) levels on the cardiovascular risk and poor control of cardiovascular risk factors in hypertensive or obese patients, with no previous diagnosis of diabetes mellitus (i.e., diagnostic inertia). A cross-sectional study during a preventive program in a Spanish region was performed in 2003-2004. The participants were aged ≥40 years and did not have diabetes but were hypertensive (n = 5, 347) or obese (n = 7, 833). The outcomes were high cardiovascular risk (SCORE ≥5%), poor control of the blood pressure (≥140/90 mmHg) and class II obesity. The relationship was examined between FBG and the main parameters, calculating the adjusted odd ratios with multivariate models. Higher values of FBG were associated with all the outcomes. A more proactive attitude towards the diagnosis of diabetes mellitus in the hypertensive and obese population should be adopted.

摘要

关于糖尿病诊断惰性可能产生的心血管后果的文献很少。我们研究了未被检测出的高空腹血糖(FBG)水平对高血压或肥胖患者心血管风险以及心血管危险因素控制不佳(即诊断惰性,此前未诊断出糖尿病)的影响。2003年至2004年在西班牙一个地区的预防项目中进行了一项横断面研究。参与者年龄≥40岁,无糖尿病,但患有高血压(n = 5347)或肥胖(n = 7833)。结局指标为高心血管风险(SCORE≥5%)、血压控制不佳(≥140/90 mmHg)和Ⅱ级肥胖。研究了FBG与主要参数之间的关系,用多变量模型计算调整后的比值比。较高的FBG值与所有结局相关。对于高血压和肥胖人群,应采取更积极主动的态度来诊断糖尿病。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/85db/4411519/e908c3cacf16/peerj-03-914-g001.jpg

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