[血浆白细胞介素-6、C反应蛋白及肿瘤坏死因子-α在主动脉夹层患者中的临床意义]
[Clinical significances of plasma interleukin-6,C-reaction protein and tumor necrosis factor-alpha in patients with aortic dissection].
作者信息
Zhong Ming-hua, Gu Jun, Zhang Er-yong
出版信息
Sichuan Da Xue Xue Bao Yi Xue Ban. 2015 Mar;46(2):234-7.
OBJECTIVE
To investigate the clinical significances of plasma IL-6, CRP and TNF-alpha concentration changes in aortic dissection.
METHODS
Plasma concentrations of IL-6, TNF-alpha and CRP were determined in 68 aortic dissection patients,50 patients with essential hypertensionand 50 healthy volunteers. The changes of plasma IL-6, CRP and TNF-alpha concentration were analyzed in aortic group along with the progression of the disease which was divided into 9 differenttime courses.
RESULTS
Compared with essential hypertension and healthy control group, significantly elevated CRP, IL-6 and TNF-alpha concentrations were detected in aortic dissection patients (P<0.05, respectively). All the concentrations of CRP, IL-6 and TNF-alpha reached the peak in acute phase of aortic dissection and then gradually declined in subacute and chronic phase.
CONCLUSION
Increased plasma inflammatory factors were significantly associated with aortic dissection.
目的
探讨血浆白细胞介素-6（IL-6）、C反应蛋白（CRP）及肿瘤坏死因子-α（TNF-α）浓度变化在主动脉夹层中的临床意义。
方法
测定68例主动脉夹层患者、50例原发性高血压患者及50例健康志愿者血浆中IL-6、TNF-α及CRP的浓度。将主动脉夹层组患者按病程分为9个不同时段，分析血浆IL-6、CRP及TNF-α浓度的变化情况。
结果
与原发性高血压组和健康对照组相比，主动脉夹层患者血浆CRP、IL-6及TNF-α浓度显著升高（P均<0.05）。CRP、IL-6及TNF-α浓度在主动脉夹层急性期均达到峰值，随后在亚急性期和慢性期逐渐下降。
结论
血浆炎症因子升高与主动脉夹层显著相关。
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