钴催化的分子间C(sp(2))-O交叉偶联反应。

Cobalt-catalyzed intermolecular C(sp(2))-O cross-coupling.

作者信息

Kundu Debasish, Tripathy Manisha, Maity Pintu, Ranu Brindaban C

机构信息

Department of Organic Chemistry, Indian Association for the Cultivation of Science, Jadavpur, Kolkata-700032 (India).

Department of Chemistry, IIT-Guwahati, Guwahati-781039 (India).

出版信息

Chemistry. 2015 Jun 8;21(24):8727-32. doi: 10.1002/chem.201500058. Epub 2015 Apr 29.

DOI:10.1002/chem.201500058

PMID:25926040

Abstract

Cobalt(II)-catalyzed C(sp(2) )O cross-coupling between aryl/heteroaryl alcohols and vinyl/aryl halides in the presence of Cu(I) has been achieved under ligand-free conditions. In this reaction, copper plays a significant role in transmetalation rather than being directly involved in the CO coupling. This unique Co/Cu-dual catalyst system provides an easy access to a library of aryl-vinyl, heteroaryl-styryl, aryl-aryl, and heteroaryl-heteroaryl ethers in the absence of any ligand or additive.

摘要

在无配体条件下，实现了钴（II）催化的芳基/杂芳基醇与乙烯基/芳基卤化物之间的C(sp(2) )—O交叉偶联反应。在该反应中，铜在金属转移过程中发挥重要作用，而非直接参与C—O偶联。这种独特的钴/铜双催化剂体系无需任何配体或添加剂，就能方便地合成一系列芳基-乙烯基、杂芳基-苯乙烯基、芳基-芳基和杂芳基-杂芳基醚。