通过铜（I）催化的6-内型环化反应合成多取代的1,6-二氢吡啶。

Synthesis of multiply substituted 1,6-dihydropyridines through Cu(I)-catalyzed 6-endo cyclization.

作者信息

Mizoguchi Haruki, Watanabe Ryo, Minami Shintaro, Oikawa Hideaki, Oguri Hiroki

机构信息

Division of Chemistry, Graduate School of Science, Hokkaido University, N10 W8, Sapporo 060-0810, Japan.

出版信息

Org Biomol Chem. 2015 Jun 7;13(21):5955-63. doi: 10.1039/c5ob00356c.

DOI:10.1039/c5ob00356c

PMID:25927165

Abstract

Copper-catalyzed 6-endo cyclization of N-propargylic β-enaminocarbonyls was developed for the synthesis of oxidation-labile 1,6-dihydropyridines. This synthetic method allows flexible and regio-defined assembly of various substituents at the N1, C2, C3, C4, and C6 positions of 1,6-dihydropyridines under mild conditions.

摘要

铜催化的N-炔丙基β-烯胺羰基化合物的6-内型环化反应被用于合成对氧化敏感的1,6-二氢吡啶。这种合成方法能够在温和条件下，在1,6-二氢吡啶的N1、C2、C3、C4和C6位灵活且区域定向地组装各种取代基。