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Aging stem cells. A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging.
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Ageing: Heterochromatin disorganization associated with premature ageing.
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The Werner syndrome protein: linking the replication checkpoint response to genome stability.
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Stem Cell Depletion by Global Disorganization of the H3K9me3 Epigenetic Marker in Aging.
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Medicine. Progeria accelerates adult stem cell aging.
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Role of Werner syndrome gene product helicase in carcinogenesis and in resistance to genotoxins by cancer cells.
Cancer Sci. 2008 May;99(5):843-8. doi: 10.1111/j.1349-7006.2008.00778.x. Epub 2008 Feb 26.
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Werner syndrome (WRN) gene variants and their association with altered function and age-associated diseases.
Ageing Res Rev. 2018 Jan;41:82-97. doi: 10.1016/j.arr.2017.11.003. Epub 2017 Nov 14.

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Epigenetic Regulation of Aging and its Rejuvenation.
MedComm (2020). 2025 Sep 1;6(9):e70369. doi: 10.1002/mco2.70369. eCollection 2025 Sep.
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Aere perennius: how chromatin fidelity is maintained and lost in disease.
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Glial reactivity and cognitive decline follow chronic heterochromatin loss in neurons.
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An overview of RecQ helicases and related diseases.
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Gene therapy strategies for aging intervention.
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Werner syndrome exonuclease promotes gut regeneration and causes age-associated gut hyperplasia in Drosophila.
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RIG-I-driven CDKN1A stabilization reinforces cellular senescence.
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Human iPSC-based modeling of late-onset disease via progerin-induced aging.
Cell Stem Cell. 2013 Dec 5;13(6):691-705. doi: 10.1016/j.stem.2013.11.006.
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Concealing cellular defects in pluripotent stem cells.
Trends Cell Biol. 2013 Dec;23(12):587-92. doi: 10.1016/j.tcb.2013.07.001. Epub 2013 Aug 1.
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The hallmarks of aging.
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Methylation of SUV39H1 by SET7/9 results in heterochromatin relaxation and genome instability.
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Progressive degeneration of human neural stem cells caused by pathogenic LRRK2.
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iPSC technology to study human aging and aging-related disorders.
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Recapitulation of premature ageing with iPSCs from Hutchinson-Gilford progeria syndrome.
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Four faces of cellular senescence.
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