Liang Zhongshu, Jiang Weihong, Ouyang Mao, Yang Kan
Department of Cardiology, The Third Xiangya Hospital of Central South University 138 Tongzipo Road, Changsha 410013, Hunan, China.
Int J Clin Exp Med. 2015 Feb 15;8(2):2097-107. eCollection 2015.
Many epidemiologic studies have investigated the plasminogen activator inhibitor-1 (PAI-1) gene 4G/5G polymorphism and this association with coronary artery disease (CAD). But definite conclusions can not be drawn. Related studies were identified from PubMed, Springer Link, Ovid, Chinese Wanfang Data Knowledge Service Platform, Chinese National Knowledge Infrastructure (CNKI), and Chinese Biology Medicine (CBM) till 10 August 2014. Pooled ORs and 95% CIs were used to assess the strength of the associations. A total of 53 studies including 20921 CAD cases and 18434 controls were included. Significantly elevated CAD risk was found in overall analysis (OR = 1.13, 95% CI: 1.05-1.21, P = 0.0009). In the subgroup analysis by races, significantly increased risk was found in Caucasians (OR = 1.11, 95% CI: 1.03-1.20, P = 0.005) and Asians (OR = 1.20, 95% CI: 1.01-1.42, P = 0.04). In the subgroup analysis by gender, significant association was found in males (OR = 1.15, 95% CI: 1.06-1.25, P = 0.0008), but was not found in females (OR = 1.05, 95% CI: 0.92-1.20, P = 0.47). In the subgroup analysis by age, young populations showed increased CAD risk (OR = 1.19, 95% CI: 1.02-1.37, P = 0.02), but old populations did not show this association (OR = 1.01, 95% CI: 0.82-1.24, P = 0.93). This meta-analysis provides the evidence that PAI-1 4G/5G polymorphism may contribute to the CAD development.
许多流行病学研究调查了纤溶酶原激活物抑制剂-1（PAI-1）基因4G/5G多态性及其与冠状动脉疾病（CAD）的关联。但尚未得出明确结论。截至2014年8月10日，从PubMed、Springer Link、Ovid、中国万方数据知识服务平台、中国知网（CNKI）和中国生物医学数据库（CBM）中检索到相关研究。采用合并OR值和95%可信区间（CI）评估关联强度。共纳入53项研究，包括20921例CAD病例和18434例对照。总体分析发现CAD风险显著升高（OR = 1.13，95%CI：1.05 - 1.21，P = 0.0009）。种族亚组分析中，白种人（OR = 1.11，95%CI：1.03 - 1.20，P = 0.005）和亚洲人（OR = 1.20，95%CI：1.01 - 1.42，P = 0.04）的风险显著增加。性别亚组分析中，男性存在显著关联（OR = 1.15，95%CI：1.06 - 1.25，P = 0.0008），而女性未发现（OR = 1.05，95%CI：0.92 - 1.20，P = 0.47）。年龄亚组分析中，年轻人群CAD风险增加（OR = 1.19，95%CI：1.02 - 1.37，P = 0.02），而老年人群未显示此关联（OR = 1.01，95%CI：0.82 - 1.24，P = 0.93）。这项荟萃分析提供了证据表明PAI-1 4G/5G多态性可能与CAD的发生有关。
