肿瘤坏死因子α基因rs1800629多态性与宫颈癌风险的关联。
Association between tumor necrosis factor alpha rs1800629 polymorphism and risk of cervical cancer.
作者信息
Wang Lanling, Ma Kunpeng, Wang Zhiyong, Mou Yingying, Ma Li, Guo Yong
机构信息
Department of VIP Obstetrics and Gynecology, Weifang Maternal and Child Health Hospital Weifang 261011, Shandong, China.
Department of Otolaryngology, Affiliated Hospital of Weifang Medical University Weifang 261011, Shandong, China.
出版信息
Int J Clin Exp Med. 2015 Feb 15;8(2):2108-17. eCollection 2015.
PURPOSE
The objective of this study was to evaluate the influence of the TNF-α rs1800629 polymorphism on the risk of cervical cancer.
METHODS
A comprehensive search of EMBASE, PubMed, Wanfang database and China National Knowledge Infrastructure (CNKI) was conducted and the papers published were retrieved. The fixed effects or random effects model was appropriately used to calculate the odds ratio (OR) along with 95% confidence interval (CI).
RESULTS
Data from sixteen articles containing nineteen studies were summarized in this meta-analysis. In general, we observed a marginal association between the TNF-α rs1800629 polymorphism and cervical cancer risk under the AA + AG vs. GG comparison model (OR=1.17, 95% CI=1.00-1.38, P=0.019 for heterogeneity). Interestingly, significantly increased risk was observed in the allele model (A vs. G: OR=1.19, 95% CI=1.02-1.38, P=0.006 for heterogeneity). In the stratified analysis by ethnicity, we found significant results in Caucasians.
CONCLUSIONS
Our results reveal that the Caucasian population may be at increased risk of developing invasive cervical cancer associated with the TNF-α rs1800629 polymorphism.
目的
本研究旨在评估肿瘤坏死因子-α（TNF-α）基因rs1800629多态性对宫颈癌风险的影响。
方法
全面检索了EMBASE、PubMed、万方数据库和中国知网（CNKI），检索已发表的论文。采用固定效应或随机效应模型适当计算比值比（OR）及95%置信区间（CI）。
结果
本荟萃分析总结了16篇文章中的19项研究的数据。总体而言，在AA + AG与GG比较模型下，我们观察到TNF-α rs1800629多态性与宫颈癌风险之间存在微弱关联（OR = 1.17，95% CI = 1.00 - 1.38，异质性P = 0.019）。有趣的是，在等位基因模型中观察到风险显著增加（A与G比较：OR = 1.19，95% CI = 1.02 - 1.38，异质性P = 0.006）。在按种族进行的分层分析中，我们在白种人中发现了显著结果。
结论
我们的结果表明，白种人群可能因TNF-α rs1800629多态性而增加患浸润性宫颈癌的风险。
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