Song Guang, Liu Jing, Ren Weidong, Qiao Wei, Zhang Jing, Zhan Ying, Bi Wenjing
Department of Ultrasound, Shengjing Hospital of China Medical University, Shenyang, China.
Department of Obstetrics, First Affiliated Hospital of China Medical University, Shenyang, China.
PLoS One. 2015 May 1;10(5):e0125347. doi: 10.1371/journal.pone.0125347. eCollection 2015.
Left ventricular diastolic function is impaired during pregnancy. However, changes in left atrial (LA) function remain unclear. We aimed to evaluate changes in LA function during pregnancy using two-dimensional speckle tracking echocardiography (2DSTE).
50 pregnant and 50 healthy nulliparous (control group) women were enrolled in this study. All pregnant women were followed up postpartum in sixth-month. The LA maximum volume, LA minimal volume and LA preatrial contraction volume were obtained using biplane modified Simpson's method. LA filling volume, LA expansion index, LA ejection fraction, passive volume, passive emptying index, active volume, and active emptying index were calculated. LA longitudinal systolic strain (SS), systolic strain rate (s-SR), early diastolic strain rate (e-SR), and late diastolic strain rate (a-SR) were obtained by 2DSTE. Compared to the control group, the reservoir function was increased in pregnant patients (P<0.05); conduit function was decreased in pregnant patients (P<0.05); booster pump function was increased in pregnant patients (P<0.05). There was no statistically significant difference between the control group and postpartum group.
LA reservoir and booster pump function were increased, while conduit function was decreased during pregnancy using 2DSTE. The changes were reversible. 2DSTE can easily assess LA function during pregnancy with good repeatability.
孕期左心室舒张功能受损。然而，左心房（LA）功能的变化仍不明确。我们旨在使用二维斑点追踪超声心动图（2DSTE）评估孕期LA功能的变化。
本研究纳入了50名孕妇和50名健康未孕女性（对照组）。所有孕妇在产后6个月进行随访。采用双平面改良Simpson法获取LA最大容积、LA最小容积和LA心房收缩前容积。计算LA充盈容积、LA扩张指数、LA射血分数、被动容积、被动排空指数、主动容积和主动排空指数。通过2DSTE获得LA纵向收缩期应变（SS）、收缩期应变率（s-SR）、舒张早期应变率（e-SR）和舒张晚期应变率（a-SR）。与对照组相比，孕妇的储存功能增加（P<0.05）；管道功能降低（P<0.05）；增强泵功能增加（P<0.05）。对照组与产后组之间无统计学显著差异。
使用2DSTE评估发现，孕期LA的储存和增强泵功能增加，而管道功能降低。这些变化是可逆的。2DSTE能够轻松评估孕期LA功能，且重复性良好。
